Lynch, CJ, Shah, ZH, Allison, SJ, Ahmed, Shafiq, Ford, J, Warnock, LJ, Li, H, Serrano, M and Milner, J (2010) SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS ONE, 4 (10).
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Abstract
The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1 integrates such diverse processes remains to be elucidated.
| Item Type: | Article |
|---|---|
| Depositing User: | Paula Normington |
| URI: | https://sure.sunderland.ac.uk/id/eprint/6011 |
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6011
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ORCID for Shafiq
Ahmed
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16 Feb 2016 12:04
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04 Jun 2025 17:38
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CJ Lynch
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ZH Shah
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SJ Allison
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J Ford
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LJ Warnock
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H Li
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M Serrano
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J Milner
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