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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Unusual Adsorption Effects on Inert HPLC Components

Hambleton, Paul, Lough, John, Mills, M.J. and Maltas, J. (1995) Unusual Adsorption Effects on Inert HPLC Components. Journal of Liquid Chromatography, 18 (16). pp. 3205-3217. ISSN 10826079508010445

Item Type: Article


The use of injector loops made of the inert polymer PEEKTM was studied for the analysis of non-steroidal anti-inflammatory drugs (NSAID) using microbore LC with peak compression. Surprisingly it was found that the use of PEEK not only failed to prevent adsorption of analyte in the loop but, in this instance, actually exacerbated the problem. The effect of loop overfill volume, competing NSAID in the sample solution and percentage organic component in the mobile phase on this phenomenon was investigated. Comparison was also made between PEEKTM and other materials used for injector loops.

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Depositing User: Paula Normington


Item ID: 6405
ISSN: 10826079508010445
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Date Deposited: 12 Jun 2017 10:46
Last Modified: 18 Dec 2019 15:39


Author: Paul Hambleton
Author: John Lough
Author: M.J. Mills
Author: J. Maltas

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences



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