Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Selenium Homeostasis in the Central-Nervous-System of the Rat

Pullen, Robert, Schofield, M., Markham, Anthony, Lough, John and Menton, K. (1996) Selenium Homeostasis in the Central-Nervous-System of the Rat. Life Sciences, 58 (23). pp. 2125-2135.

Item Type: Article


These experiments have investigated selenium movement between blood and CNS in anaesthetised rats. Each animal was surgically anaesthetised and the left femoral blood vessels cannulated for blood withdrawal and solute infusion. Each rat received 75-selenium as sodium selenite infused in normal saline and experiments lasted between 5 minutes and 5 hours during which blood samples were periodically taken. At termination, the CNS was removed, regionally dissected and analysed with the plasma samples for 75-Se radioactivity by gamma-counting. Data were analysed by graphical analysis. Results showed unidirectional uptake of 75-Se into the CNS and regional differences were not found except for the hypothalamus. On average the CNS influx rate constant (Kin) was about 7 +/- 1 x 10(-5) ml/min/g. Data suggest that the 75-Se most likely entered the CNS as a free ionic form.

Full text not available from this repository.

More Information

Depositing User: Paula Normington


Item ID: 6415
Identification Number:
Official URL:

Users with ORCIDS

Catalogue record

Date Deposited: 11 Jun 2017 14:13
Last Modified: 18 Dec 2019 15:39


Author: Robert Pullen
Author: M. Schofield
Author: Anthony Markham
Author: John Lough
Author: K. Menton

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences



Actions (login required)

View Item View Item