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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Allosteric Integrase Inhibitors

Hann, Victoria, Dawson, Peter and Ashton, Mark (2016) Allosteric Integrase Inhibitors. In: Frontiers in Clinical Drug Research-HIV. Bentham Science Publishers, UAE, pp. 49-126. ISBN 9781681082301

Item Type: Book Section


In the recent years, integrase (IN) has emerged as an important new target for the development of anti-HIV-1 agents. The enzyme is involved in a key stage of the retroviral replicative cycle, and interacts with a range of cellular co-factors. Due to the absolute necessity of the enzyme for successful infection and the range of cellular cofactors employed by the enzyme, new ways of targeting both IN and its cofactors could yield agents with improved resistance profiles. Allosteric inhibitors are currently receiving a great deal of focus from both academia and industry alike and offer the possibility of a new class of anti-HIV-1 inhibitor.

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Depositing User: Barry Hall


Item ID: 6903
Identification Number:
ISBN: 9781681082301
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Catalogue record

Date Deposited: 30 Jan 2017 16:29
Last Modified: 02 Jun 2021 10:54


Author: Victoria Hann
Author: Peter Dawson
Author: Mark Ashton

University Divisions

Faculty of Health Sciences and Wellbeing


Sciences > Biomedical Sciences

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