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High sensitivity of brain octopamine levels to stress

Ennaceur, Abdelkader, Coulon, JF, Delacour, Jean and David, Jean Claude (1986) High sensitivity of brain octopamine levels to stress. Psychopharmacology, 88 (3). pp. 305-309. ISSN 0033-3158

Item Type: Article


Rats were submitted to unsignalled and uncontrolled electrical shocks. When re-exposed to the same situation but not shocked, 24 h later, their locomotor activity was significantly reduced compared to that of controls. This conditioned suppression was associated with a significant decrease in p-octopamine (OA) in brain stem and hypothalamus. Shocks delivered just before brain fixation produced an even larger decrease in cerebral OA. Heart levels of OA were not affected. Cerebral and peripheral levels of dopamine and noradrenaline were not significantly or reliably affected. These results, as those of previous experiments, suggest that octopamine is involved in emotional, neurovegetative responses to stress.

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Depositing User: Abdelkader Ennaceur


Item ID: 8102
Identification Number:
ISSN: 0033-3158
Official URL: h

Users with ORCIDS

ORCID for Abdelkader Ennaceur: ORCID iD

Catalogue record

Date Deposited: 13 Nov 2017 15:54
Last Modified: 18 Dec 2019 15:41


Author: Abdelkader Ennaceur ORCID iD
Author: JF Coulon
Author: Jean Delacour
Author: Jean Claude David

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Biomedical Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology

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