Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Unlicensed medicines use: A UK guideline analysis using AGREE II

Donovan, Gemma, Parkin, Lindsay, Brierley-Jones, Lyn and Wilkes, Scott (2018) Unlicensed medicines use: A UK guideline analysis using AGREE II. International Journal of Pharmacy Practice. ISSN 2042-7174

Item Type: Article


Rationale, aims and objectives
There is widespread use of unlicensed medicines within primary and secondary care but little information is available around how these medicines are used. This analysis examines and evaluates the content and quality of relevant guidance documentation currently in use within the UK.

Guidance documents were identified through a literature search as well as email requests to pharmacy organisations throughout the UK . Unlicensed medicine documentation suitable for inclusion in the analysis underwent thematic analysis and quality assessment using the AGREE II tool.

Thematic analysis of 52 guidelines revealed four parent themes:
i. Professional responsibility
ii. Usage practicalities
iii. Risk versus benefit
iv. Controlling use.

There was variability in scores across the AGREE II domains with areas covering Scope and Purpose and Clarity of Presentation scoring well. Conversely, an area needing attention was Rigour of Development.

Healthcare organisations would benefit from agreeing a ‘core content’ for the development of unlicensed medicines guidelines to ensure consistency and the presence of robust operating systems to deliver safe, effective treatment to all NHS patients.

IJPP_EMULSION_Guideline_Analysis_Accepted.pdf - Accepted Version

Download (290kB) | Preview

More Information

Depositing User: Gemma Donovan


Item ID: 8491
Identification Number:
ISSN: 2042-7174
Official URL:

Users with ORCIDS

ORCID for Scott Wilkes: ORCID iD

Catalogue record

Date Deposited: 23 Mar 2018 15:30
Last Modified: 18 Dec 2019 16:05


Author: Scott Wilkes ORCID iD
Author: Gemma Donovan
Author: Lindsay Parkin
Author: Lyn Brierley-Jones

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Nursing
Sciences > Pharmacy and Pharmacology

Actions (login required)

View Item View Item