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Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms†

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Cellier-Rastit, Marie, Chalansonnet, Valerie, James, Arthur L, Johnston, Annette, Orenga, Sylvain, Perry, John D., Roger-Dalbert, Celine, Salwatura, Vindhya L, Stanforth, Stephen P, Sykes, Hannah E and Truong, Viet T (2023) Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms†. Journal of Materials Chemistry B, 11. pp. 6106-6113. ISSN 2050-7518

Item Type: Article

Abstract

A series of [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives have been synthesised as potential indicators of microbial nitroreductase activity. When assessed against a selection of 20 clinically important pathogenic microorganisms, microbial colonies of various colours (yellow, green, red, brown, black) were produced and attributed to nitroreductase activity. Most substrates elicited colour responses with Gram-negative microorganisms. In contrast, the growth of several species of Gram-positive microorganisms and yeasts was often inhibited by the substrates and hence coloured responses were not seen.

Graphical abstract: Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms

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More Information

Depositing User: Thang Truong

Identifiers

Item ID: 16449
Identification Number: https://doi.org/10.1039/d3tb00715d
ISSN: 2050-7518
URI: http://sure.sunderland.ac.uk/id/eprint/16449
Official URL: https://pubs.rsc.org/en/content/articlelanding/202...

Users with ORCIDS

ORCID for Viet T Truong: ORCID iD orcid.org/0009-0005-3289-2984

Catalogue record

Date Deposited: 31 Jul 2023 09:49
Last Modified: 31 Jul 2023 09:49

Contributors

Author: Viet T Truong ORCID iD
Author: Marie Cellier-Rastit
Author: Valerie Chalansonnet
Author: Arthur L James
Author: Annette Johnston
Author: Sylvain Orenga
Author: John D. Perry
Author: Celine Roger-Dalbert
Author: Vindhya L Salwatura
Author: Stephen P Stanforth
Author: Hannah E Sykes

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Chemistry
Sciences > Health Sciences
Sciences > Pharmacy and Pharmacology

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