A

Abdelkader, Dalia H., El-Gizawy, Sanaa A., Faheem, Ahmed, McCarron, Paul A. and Osman, Mohamed A. (2018) Effect of process variables on formulation, in-vitro characterisation and subcutaneous delivery of insulin PLGA nanoparticles: An optimisation study. Journal of Drug Delivery Science and Technology, 43. pp. 160-171. ISSN 17732247

Abeke, Egega (2017) Dietary Analysis of Barley Crop for Animal Feed Supplementation in Poultry Farming. Doctoral thesis, University of Sunderland.

Andersen, O.A., Nathubhai, Amit, Dixon, M.J., Eggleston, I.M. and van Aalten, D.M.F. (2008) Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin. Chemistry & Biology, 15 (3). pp. 295-301. ISSN 1074-5521

Anderson, Rosaleen, Groundwater, Paul, Todd, Adam and Worsley, Alan (2012) Antibacterial agents: chemistry, mode of action, mechanisms of resistance and clinical applications. Wiley Blackwell. ISBN ISBN: 978-0-470-97245-8

C

Cherian, Thomas (2014) A Functional Study of the Ureter: Relevance of Myogenic and Neurogenic Functions and the Role of Post-Synaptic Alpha 1 and Alpha 2 Adrenergic Recepters in Ureteral Motility. Doctoral thesis, University of Sunderland.

Childs, Stephen, Haroune, Nicolas, Williams, Lee and Gronow, Michael (2017) Investigation of the Low Molecular Weight Thiol Composition in a Metastatic Prostate Cancer Cell Line (LNCaP) by LC-UV-MS and NMR after Labelling with the Ellman Reagent. American Journal of Analytical Chemistry, 08 (01). pp. 1-18. ISSN 2156-8251

Colombano, Giampiero, Caldwell, John J, Matthews, Thomas Peter, Bhatia, Chitra, Joshi, Amar, McHardy, Tatiana, Mok, Ngai Yi, Newbatt, Yvette, Pickard, Lisa, Strover, Jade, Hedayat, Somaieh, Walton, Michael Ian, Myers, Stephanie, Jones, Alan Morenc, Saville, Harry, McAndrew, Craig, Burke, Rosemary, Eccles, Suzanne, Davies, Faith, Bayliss, Richard and Collins, Ian (2019) Binding to an unusual inactive kinase conformation by highly selective inhibitors of inositol-requiring enzyme 1α kinase-endoribonuclease. Journal of Medicinal Chemistry, 62 (5). pp. 2447-2465. ISSN 0022-2623

D

Dixon, M.J., Andersen, O.A., van Aalten, D. M. F., Nathubhai, Amit and Eggleston, I.M. (2007) Cyclic peptide chitinase inhibitors: New leads for antifungal and anti-inflammatory drugs. Biopolymers, 88 (4). p. 576. ISSN 0006-3525

Dixon, M.J., Andersen, O.A., van Aalten, D.M.F., Nathubhai, Amit and Eggleston, I.M. (2008) Synthesis of cyclic peptide chitinase inhibitors: Natural products with chemotherapeutic potential. Journal of Peptide Science, 14 (8). p. 13. ISSN 1075-2617

Dixon, M.J., Giuntini, F., Nathubhai, Amit, Andersen, O.A., van Aalten, D.M.F. and Eggleston, I.M. (2008) Synthetic approaches to cyclic peptide natural products as chitinase inhibitors. Journal of Peptide Science, 14 (8). p. 55. ISSN 1075-2617

Dixon, M.J., Nathubhai, Amit, Andersen, O.A., van Aalten, D.M.F. and Eggleston, I.M. (2008) Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold. Organic & Biomolecular Chemistry, 7. pp. 259-268. ISSN 1477-0520

Dixon, M.J., Nathubhai, Amit, Andersen, O.A., van Aalten, D.M.F. and Eggleston, I.M. (2009) Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: New leads for antifungal and anti-inflammatory drugs. Advances in Experimental Medicine and Biology, 611. pp. 525-526. ISSN 0065-2598

E

Elkordy, Amal, Forbes, Robert T and Barry, Brian W (2008) Study of protein conformational stability and integrity using calorimetry and FT-Raman spectroscopy correlated with enzymatic activity. European Journal of Pharmaceutical Sciences, 33 (2). pp. 177-190. ISSN 0928-0987

F

Fatouros, Dimitrios, Douroumis, D, Nikolakis, V, Ntais, S, Moschovi, Anastasia Maria, Trivedi, V, Khima, B, Roldo, Marta, Nazar, Hamde and Cox, Paul (2011) In vitro and in silico investigations of drug delivery via zeolite BEA. Journal of Materials Chemistry (21). pp. 7789-7794. ISSN 0959-9428

G

Gray, Mark and Harburn, James (2011) Dynamic Covalent Chemistry in Fragment-based Drug Design. In: Encyclopedia of Supramolecular Chemistry. Taylor & Francis, pp. 1-9. ISBN 0-8247-5056-X

H

Harburn, Jonathan (2011) Dynamic Covalent Chemistry in Fragment-Based Drug Discovery. In: Encyclopedia of Supramolecular Chemistry. Taylor & Francis, pp. 1-9. ISBN 0-8247-5056-X

Heritage, John, McDonald, Sharon and McGarry, Kenneth (2017) Integrating association rules mined from health-care data with ontological information for automated knowledge generation. In: The 17th Annual UK Workshop on Computational Intelligence (UKCI-2017), 6-8 Sep 2017, Cardiff. (In Press)

K

Khattab, RA, Elbandy, M, Lawrence, A, Paget, Timothy, Rae-Rho, J, Binnaser, YS and Ali, I (2018) Extraction, identification and biological activities of saponins in sea cucumber Pearsonothuria graeffei. Comb Chem High Throughput Screen, 21 (3). pp. 222-231. ISSN 1386-2073

Kumpan, K., Nathubhai, Amit, Zhang, C., Wood, P.J., Lloyd, M.D., Thompson, A.S., Haikarainen, T., Lehtiö, L. and Threadgill, M.D. (2015) Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Bioorganic & Medicinal Chemistry, 23. pp. 3013-3032. ISSN 0968-0896

M

Mahita, Mwajuma, Abuhamdah, Rushdie, Howes, Melanie-Jayne, Ennaceur, Abdelkader, Abuhamdah, S and Chazot, Paul (2014) Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils. European Journal of Medicinal Plants, 4 (7). pp. 810-818. ISSN 2231-0894

McGarry, Kenneth and Assamoha, Ennock (2017) Data integration with self-organising neural network reveals chemical structure and therapeutic effects of drug ATC codes. In: The 17th Annual UK Workshop on Computational Intelligence (UKCI-2017), 6-8 Sep 2017, Cardiff. (In Press)

McGarry, Kenneth, Graham, Yitka, McDonald, Sharon and Rashid, Anuam (2018) RESKO: Repositioning drugs by using side effects and knowledge from ontologies. Knowledge-Based Systems. pp. 34-48. ISSN 09507051

McGarry, Kenneth and MacIntyre, John (1999) Hybrid diagnostic system based upon simulation and artificial intelligence. In: Condition monitoring '99: International Conference on Condition Monitoring, 12-16 Apr 1999, University of Wales, Swansea.

McGarry, Kenneth and MacIntyre, John (1999) Knowledge extraction and insertion from radial basis function networks. In: IEE Colloquium on Applied Statistical Pattern Recognition, 20 Apr 1999, Birmingham, UK. (Unpublished)

McGarry, Kenneth, Tait, John, Wermter, Stefan and MacIntyre, John (1999) Rule extraction from radial basis function networks. In: 9th International Conference on Artificial Neural Networks, 7-10 Sep 1999, Edinburgh, UK.

McGarry, Kenneth, Wermter, Stefan and MacIntyre, John (1999) Knowledge extraction from radial basis function networks and multi-layer perceptrons. In: International Joint Conference on Neural Networks, 10-16 Jul 1999, Washington DC , USA. (Unpublished)

Cancer Research Technology Ltd (2016) Pyrrolcarboxamide derivatives for the inhbition of erk5. PCT/GB2015/052707.

Myers, Stephanie, Bawn, Ruth H., Bisset, Louise C., Blackburn, Timothy J., Cottyn, Betty, Molyneux, Lauren, Wong, Ai-Ching, Cano, Celine, Clegg, William, Harrington, Ross. W., Leung, Hing, Rigoreau, Laurent, Vidot, Sandrine, Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Newell, David R. and Hardcastle, Ian R. (2016) High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors. ACS Combinatorial Science, 18 (8). pp. 444-455. ISSN 2156-8952

Myers, Stephanie and Collins, Ian (2016) Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy. Future Medicinal Chemistry, 8 (4). pp. 463-489. ISSN 1756-8919

N

Nathubhai, Amit, Haikarainen, T, Hayward, P.C., Munoz-Descalzo, S., Thompson, A.S., Lloyd, M.D., Lehtio, L. and Threadgill, M.D. (2016) Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. European Journal of Medicinal Chemistry, 118. pp. 316-327. ISSN 0223-5234

Nathubhai, Amit, Haikarainen, T., Koivunen, J., Murthy, S., Koumanov, F., Lloyd, M.D., Holman, J.D., Pihlajaniemi, T., Tosh, D., Lehtiö, L. and Threadgill, M.D. (2016) Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. Journal of Medicinal Chemistry, 60 (2). pp. 814-820. ISSN 0022-2623

Nathubhai, Amit, Patterson, R., Woodman, T.J., Sharp, H.E.C., Chui, M.T.Y., Chung, H.H.K., Lau, W.S., Zheng, J., Lloyd, M.D., Thompson, A.S. and Threadgill, M.D. (2011) N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic & Biomolecular Chemistry, 9. pp. 6089-6099. ISSN 1477-0520

Nathubhai, Amit, Threadgill, M D (2016) New potent and selective tankyrase inhibitors for the treatment of disease or conditions associated with Wnt signalling e.g. colon cancer, prostate cancer, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and type-1/type-2 diabetes. WO2017-GB52624.

Nathubhai, Amit, Wood, P.J., Lloyd, M.D., Thompson, A.S. and Threadgill, M.D. (2013) Design and Discovery of 2‑Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases. ACS Medicinal Chemistry Letters, 4 (12). pp. 1173-1177. ISSN 1948-5875

Nazar, Hamde, Roldo, Marta, Fatouros, Dimitrios, van der Merwe, S M and Tsibouklis, John (2012) Hydrogel for mucosal drug delivery. Therapeutic delivery, 3 (4). pp. 535-555. ISSN 2041-5990

O

Ousset, Aymeric, Chavez, Pierre-François, Meeus, Joke, Robin, Florent, Schubert, Martin Alexander, Somville, Pascal and Dodou, Kalliopi (2018) Prediction of Phase Behavior of Spray-Dried Amorphous Solid Dispersions: Assessment of Thermodynamic Models, Standard Screening Methods and a Novel Atomization Screening Device with Regard to Prediction Accuracy. Pharmaceutics, 10 (1). pp. 29-54. ISSN 1999-4923; CODEN: PHARK5

P

Paget, Timothy (2017) The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei. Scientific reports, 7 (923). ISSN 2045-2322

Paine, H.A., Nathubhai, Amit, Woon, E.C.Y., Sunderland, P.T., Wood, P.J., Mahon, M.F., Lloyd, M.D., Thompson, A.S., Haikarainen, T., Narwal, M., Lehtiö, L. and Threadgill, M.D. (2015) Exploration of the nicotinamide-binding site of the tankyrases,identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Bioorganic & Medicinal Chemistry, 23. pp. 5891-5908. ISSN 0968-0896

T

Tindle, John, Gray, Mark, Warrender, Robert, Ginty, Kevin and Dawson, Peter (2014) Further Development of an Application Framework for Computational Chemistry (AFCC) Applied to New Drug Discovery. In: Contemporary Advancements in Information Technology Development in Dynamic Environments. IGI Global, USA, pp. 92-210. ISBN 1466662522

Twum, E.A., Nathubhai, Amit, Wood, P.J., Lloyd, M.D., Thompson, A.S. and Threadgill, M.D. (2015) Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems. Bioorganic & Medicinal Chemistry, 23. pp. 3481-3489. ISSN 0968-0896

V

Varadi, Linda, Gray, Mark, Groundwater, Paul, Hall, Andrew, James, Arthur L, Orenga, Sylvain, Perry, John D and Anderson, Rosaleen (2012) Synthesis and evaluation of fluorogenic 2-amino-1,8-naphthyridine derivatives for the detection of bacteria. Organic & Biomolecular Chemistry, 10 (13). pp. 2578-2589. ISSN 1477-0520

Y

Yevglevskis, M., Lee, G. L, Nathubhai, Amit, Petrova, Y.D., James, T.D., Threadgill, M.D., Woodman, T.J and Lloyd, M.D. (2018) Structure-activity relationships of rationally designed AMACR 1A inhibitors. BIOORGANIC CHEMISTRY, 79. pp. 145-154. ISSN 0045-2068

Yevglevskis, M., Lee, G.L., Nathubhai, Amit, Petrova, Y.D., James, T.D., Threadgill, M.D., Woodman, T.J. and Lloyd, M.D. (2017) A novel colorimetric assay for alpha-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate. Chemical Communications, 53 (37). pp. 5073-5240. ISSN 1359-7345

Yitka, Graham (Unspecified 27) PROACT: Preventing pressure ulcers in care homes. In: NHS England Extended Health in Care Homes, March 27th 2018, Penrith, Cumbria. (Unpublished)

Z

Zaytsev, Andrey V, Anderson, Rosaleen, Bedernjak, Alexandre, Groundwater, Paul, Huang, Yongxue and Perry, John D (2008) Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase. Organic and Biomolecular Chemistry, 6 (4). pp. 682-692. ISSN 1477-0520

Zhang, Weimin, Ning, Fuquiang, Varadi, Linda, Hibbs, David E., Platts, James A., Nyerges, Miklos, Anderson, Rosaleen and Groundwater, Paul (2014) An investigation of the scope of the 1,7-electrocyclization of α,b:γ,δ-conjugated azomethine ylides. Tetrahedron, 70 (22). pp. 3621-3629. ISSN 0040-4020