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Preparation of novel optimum liquisolid compacts via incorporating water granulation process to enhance the powder characterizations and dissolution behavior of a poorly soluble drug: Norfloxacin

Said Suliman, Ammar, Anderson, Rosaleen and Elkordy, Amal (2019) Preparation of novel optimum liquisolid compacts via incorporating water granulation process to enhance the powder characterizations and dissolution behavior of a poorly soluble drug: Norfloxacin. Powder Technology. ISSN 0032-5910

Item Type: Article

Abstract

The aim of this work is to investigate the addition of wet granulation technique into liquisolid process in order to enhance the characterizations of liquisolid compacts, such as flowability, compressibility and the percentage of drug release (using norfloxacin as a model of poorly soluble-permeable drug) in neutral dissolution medium. The water in the liquisolid formulations works as a liquid binder to the carrier and coating particles, creating a wider space inside their structure, which allows the amount of the liquid vehicle (PEG200 or Synperonic ™ PE/L-61) to increase inside the formulations. This feature reflects positively on: the flowability (decreasing the angle of the slide up to 10 degrees), the compressibility (increasing the load factor from 0.2 to >0.4 in PEG200 liquisolid compacts and from 0.14 to 0.29 in the case of Synperonic ™ PE/L-61iquisolid compacts) and the dissolution behaviour of norfloxacin (increasing drug release). The applied accelerated stability study on the water granulated liquisolid compacts showed no significant differences in the dissolution profiles. Also, the DSC thermographs indicated that the water granulated liquisolid compacts resist the applied stressful conditions. As a consequence, the positive outcomes of the combination between liquisolid and water granulation process open the door for robust tablet production on a large scale in pharmaceutical industries.

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More Information

Depositing User: Amal Elkordy

Identifiers

Item ID: 10854
Identification Number: https://doi.org/10.1016/j.powtec.2019.05.071
ISSN: 0032-5910
URI: http://sure.sunderland.ac.uk/id/eprint/10854
Official URL: https://www.sciencedirect.com/science/article/pii/...

Users with ORCIDS

ORCID for Amal Elkordy: ORCID iD orcid.org/0000-0002-0781-1127

Catalogue record

Date Deposited: 13 Jun 2019 10:32
Last Modified: 16 May 2022 13:01

Contributors

Author: Amal Elkordy ORCID iD
Author: Ammar Said Suliman
Author: Rosaleen Anderson

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Pharmacy and Pharmacology

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