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Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian, Zahra, Nobili, Stefania, Peyravian, Noshad, Shojaee, Bahador, Nazari, Haniye, Soleimani, Hiva, Asadzadeh-Aghdaei, Hamid, Ashrafian Bonab, Maziar, Nazemalhosseini-Mojarad, Ehsan and Mini, Enrico (2021) Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer. Cancers. ISSN 2072-6694

Item Type: Article

Abstract

Abstract
Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis.

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More Information

Depositing User: Maziar Ashrafian Bonab

Identifiers

Item ID: 14260
Identification Number: https://doi.org/10.3390/cancers13246226
ISSN: 2072-6694
URI: http://sure.sunderland.ac.uk/id/eprint/14260
Official URL: https://www.mdpi.com/journal/cancers

Users with ORCIDS

ORCID for Maziar Ashrafian Bonab: ORCID iD orcid.org/0000-0002-9833-7976

Catalogue record

Date Deposited: 17 Dec 2021 15:16
Last Modified: 25 Jan 2022 08:47

Contributors

Author: Maziar Ashrafian Bonab ORCID iD
Author: Zahra Pezeshkian
Author: Stefania Nobili
Author: Noshad Peyravian
Author: Bahador Shojaee
Author: Haniye Nazari
Author: Hiva Soleimani
Author: Hamid Asadzadeh-Aghdaei
Author: Ehsan Nazemalhosseini-Mojarad
Author: Enrico Mini

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Subjects

Sciences > Biomedical Sciences
Sciences > Health Sciences

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