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The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non‐teleost ray‐finned fish

Butts, Thomas, Modrell, Melinda S., Baker, Clare V.H. and Wingate, Richard J.T. (2014) The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non‐teleost ray‐finned fish. Evolution & Development, 16 (2). pp. 92-100. ISSN 1520-541X

Item Type: Article

Abstract

The cerebellum represents one of the most morphologically variable structures in the vertebrate brain. To shed light on its evolutionary history, we have examined the molecular anatomy and proliferation of the developing cerebellum of the North American paddlefish, Polyodon spathula. Absence of an external proliferative cerebellar layer and the restriction of Atonal1 expression to the rhombic lip and valvular primordium demonstrate that transit amplification in a cerebellar external germinal layer, a prominent feature of amniote cerebellum development, is absent in paddlefish. Furthermore, expression of Sonic hedgehog, which drives secondary proliferation in the mouse cerebellum, is absent from the paddlefish cerebellum. These data are consistent with what has been observed in zebrafish and suggest that the transit amplification seen in the amniote cerebellum was either lost very early in the ray-finned fish lineage or evolved in the lobe-finned fish lineage. We also suggest that the Atoh1-positive proliferative valvular primordium may represent a synapomorphy (shared derived character) of ray-finned fishes. The topology of valvular primordium development in paddlefish differs significantly from that of zebrafish and correlates with the adult cerebellar form. The distribution of proliferative granule cell precursors in different vertebrate taxa is thus the likely determining factor in cerebellar morphological diversity.

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More Information

Depositing User: Leah Maughan

Identifiers

Item ID: 14347
Identification Number: https://doi.org/10.1111/ede.12067
ISSN: 1520-541X
URI: http://sure.sunderland.ac.uk/id/eprint/14347
Official URL: http://dx.doi.org/10.1111/ede.12067

Users with ORCIDS

ORCID for Thomas Butts: ORCID iD orcid.org/0000-0002-1781-5287

Catalogue record

Date Deposited: 19 Jan 2022 08:56
Last Modified: 19 Jan 2022 08:56

Contributors

Author: Thomas Butts ORCID iD
Author: Melinda S. Modrell
Author: Clare V.H. Baker
Author: Richard J.T. Wingate

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

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