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Genome Sequence of the Pea Aphid Acyrthosiphon pisum

Eisen, Jonathan A., Butts, Thomas and The International Aphid Genomics Consortium, (2010) Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biology, 8 (2). e1000313. ISSN 1545-7885

Item Type: Article

Abstract

Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.

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More Information

Depositing User: Leah Maughan

Identifiers

Item ID: 14353
Identification Number: https://doi.org/10.1371/journal.pbio.1000313
ISSN: 1545-7885
URI: http://sure.sunderland.ac.uk/id/eprint/14353
Official URL: http://dx.doi.org/10.1371/journal.pbio.1000313

Users with ORCIDS

ORCID for Thomas Butts: ORCID iD orcid.org/0000-0002-1781-5287

Catalogue record

Date Deposited: 18 Jan 2022 08:20
Last Modified: 18 Jan 2022 08:20

Contributors

Author: Thomas Butts ORCID iD
Author: Jonathan A. Eisen
Author: The International Aphid Genomics Consortium

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

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