The Role of Dopamine D3 Receptors in Tobacco Use Disorder: A Synthesis of the Preclinical and Clinical Literature.
Butler, Kevin, Le Foll, Bernard and Di Ciano, Patricia (2022) The Role of Dopamine D3 Receptors in Tobacco Use Disorder: A Synthesis of the Preclinical and Clinical Literature. In: Therapeutic Applications of Dopamine D3 Receptor Action. Current Topics in Behavioral Neurosciences . Springer, Berlin, Heidelberg.
Item Type: | Book Section |
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Abstract
Tobacco smoking is a significant cause of preventable morbidity and mortality globally. Current pharmacological approaches to treat tobacco use disorder (TUD) are only partly effective and novel approaches are needed. Dopamine has a well-established role in substance use disorders, including TUD, and there has been a long-standing interest in developing agents that target the dopaminergic system to treat substance use disorders. Dopamine has 5 receptor subtypes (DRD1 to DRD5). Given the localization and safety profile of the dopamine receptor D3 (DRD3), it is of therapeutic potential for TUD. In this chapter, the preclinical and clinical literature investigating the role of DRD3 in processes relevant to TUD will be reviewed, including in nicotine reinforcement, drug reinstatement, conditioned stimuli and cue-reactivity, executive function, and withdrawal. Similarities and differences in findings from the animal and human work will be synthesized and findings will be discussed in relation to the therapeutic potential of targeting DRD3 in TUD.
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More Information
Uncontrolled Keywords: Dopamine; Dopamine receptor D3; Nicotine dependence; Smoking cessation; Tobacco use disorder |
Depositing User: Kevin Butler |
Identifiers
Item ID: 15410 |
ISSN: 1866-3370 |
URI: http://sure.sunderland.ac.uk/id/eprint/15410 | Official URL: https://doi.org/10.1007/7854_2022_392 |
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Catalogue record
Date Deposited: 11 Nov 2022 15:03 |
Last Modified: 24 Jan 2023 10:01 |
Author: | Kevin Butler |
Author: | Bernard Le Foll |
Author: | Patricia Di Ciano |
University Divisions
Faculty of Health Sciences and Wellbeing > School of PsychologySubjects
Sciences > Pharmacy and PharmacologyPsychology
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