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The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion

Hase, Yoshiki, Craggs, Lucinda, Hase, Mai, Stevenson, William, Slade, Janet, Chen, Aiqing, Liang, Di, Ennaceur, Abdelkader, Oakley, Arthur, Ihara, Masafumi, Horsburgh, Karen and Kalaria, Raj N (2018) The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion. Journal of Cerebral Blood Flow & Metabolism, 38 (1). pp. 151-165. ISSN 0271-678X

Item Type: Article

Abstract

White matter (WM) disintegration is common in the older population and is associated with vascular cognitive impairment (VCI). This study explored the effects of environmental enrichment (EE) on pathological sequelae in a mouse model of chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS). Male C57BL/6 J mice underwent BCAS or sham surgery. One-week after surgery, mice were exposed to three different degrees of EE; either standard housing conditions (std), limited 3 h exposure to EE per day (3 h) or full-time exposure to EE (full) for 12 weeks. At 13 weeks after surgery, cognitive testing was performed using a three-dimensional 9-arm radial maze. At 16 weeks after surgery, nesting ability was assessed in each mouse immediately before euthanasia. Brains retrieved after perfusion fixation were examined for WM pathology. BCAS caused WM changes, as demonstrated by corpus callosum atrophy and greater WM disintegrity. BCAS also caused impaired nesting ability and cognitive function. These pathological changes and working memory deficits were attenuated, more so by limited rather than full-time exposure to EE regime. Our results suggest that limited exposure to EE delays the onset of WM degeneration. Therefore, the implementation of even limited EE may be beneficial for patients diagnosed with VCI.

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Depositing User: Abdelkader Ennaceur

Identifiers

Item ID: 7228
Identification Number: https://doi.org/10.1177/0271678X17694904
ISSN: 0271-678X
URI: http://sure.sunderland.ac.uk/id/eprint/7228
Official URL: http://journals.sagepub.com/doi/10.1177/0271678X17...

Users with ORCIDS

ORCID for Abdelkader Ennaceur: ORCID iD orcid.org/0000-0001-6398-4383

Catalogue record

Date Deposited: 19 May 2017 12:24
Last Modified: 04 Feb 2021 16:50

Contributors

Author: Abdelkader Ennaceur ORCID iD
Author: Yoshiki Hase
Author: Lucinda Craggs
Author: Mai Hase
Author: William Stevenson
Author: Janet Slade
Author: Aiqing Chen
Author: Di Liang
Author: Arthur Oakley
Author: Masafumi Ihara
Author: Karen Horsburgh
Author: Raj N Kalaria

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Biomedical Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology

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