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Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain?

Jardri, Renaud, Hugdahl, Kenneth, Hughes, Matthew, Brunelin, Jérôme, Waters, Flavie, Alderson-Day, Ben, Smailes, Dave, Sterzer, Philipp, Corlett, Philip R., Leptourgos, Pantelis, Debbané, Martin, Cachia, Arnaud and Denève, Sophie (2016) Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain? Schizophrenia Bulletin, 42 (5). pp. 1124-1134. ISSN 0586-7614

Item Type: Article

Abstract

This review from the International Consortium on Hallucinations Research intends to question the pertinence of the excitatory-to-inhibitory (E/I) imbalance hypothesis as a model for hallucinations. A large number of studies suggest that subtle impairments of the E/I balance are involved in neurological and psychiatric conditions, such as schizophrenia. Emerging evidence also points to a role of the E/I balance in maintaining stable perceptual representations, suggesting it may be a plausible model for hallucinations. In support, hallucinations have been linked to inhibitory deficits as shown with impairment of gamma-aminobutyric acid transmission, N-methyl-d-aspartate receptor plasticity, reductions in gamma-frequency oscillations, hyperactivity in sensory cortices, and cognitive inhibition deficits. However, the mechanisms by which E/I dysfunctions at the cellular level might relate to clinical symptoms and cognitive deficits remain unclear. Given recent data advances in the field of clinical neuroscience, it is now possible to conduct a synthesis of available data specifically related to hallucinations. These findings are integrated with the latest computational frameworks of hallucinations, and recommendations for future research are provided.

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More Information

Depositing User: David Smailes

Identifiers

Item ID: 8028
Identification Number: https://doi.org/10.1093/schbul/sbw075
ISSN: 0586-7614
URI: http://sure.sunderland.ac.uk/id/eprint/8028
Official URL: https://doi.org/10.1093/schbul/sbw075

Users with ORCIDS

Catalogue record

Date Deposited: 09 Oct 2017 10:26
Last Modified: 20 Mar 2019 16:09

Contributors

Author: Renaud Jardri
Author: Kenneth Hugdahl
Author: Matthew Hughes
Author: Jérôme Brunelin
Author: Flavie Waters
Author: Ben Alderson-Day
Author: Dave Smailes
Author: Philipp Sterzer
Author: Philip R. Corlett
Author: Pantelis Leptourgos
Author: Martin Debbané
Author: Arnaud Cachia
Author: Sophie Denève

University Divisions

Faculty of Health Sciences and Wellbeing

Subjects

Psychology

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