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Carotid Artery Disease in Post-Stroke Survivors and Effects of Enriched Environment on Stroke Pathology in a Mouse Model of Carotid Artery Stenosis.

Hase, Yoshiki, Polvikoski, Tuomo M., Ihara, Masafumi, Hase, Mai, Zafar, Rayyan, Stevenson, William, Allan, Louise M., Ennaceur, Abdelkader, Horsburgh, Karen, Gallart‐Palau, Xavier, Siu, Kwan Sze and Kalaria, Raj N (2019) Carotid Artery Disease in Post-Stroke Survivors and Effects of Enriched Environment on Stroke Pathology in a Mouse Model of Carotid Artery Stenosis. Neuropathology and Applied Neurobiology, 45 (7). pp. 681-697. ISSN 1365-2990

Item Type: Article


Carotid artery disease (CAD) is an important risk factor for stroke. We first evaluated CAD and stroke pathology in elderly post-stroke survivors. To simulate CAD, we assessed long-term consequences of bilateral common carotid artery stenosis (BCAS) in mice and exposed them to environmental enrichment (EE).

Histopathological methods were used to determine degrees of CAD (% area stenosis), brain infarct types, sizes and distribution in post-stroke survivors and BCAS mice. Adult male C57BL/6J mice after BCAS or sham surgery were randomly assigned to standard housing (Std) or limited (3hrs) or full-time (Full) exposure to EE per day for 12 weeks.

High frequencies of moderate carotid artery stenosis (51-75%) were evident in post-stroke survivors whereas those with severe CAD (>75% stenosis) exhibited greater numbers of cortical rather than subcortical infarcts and, were at higher risk of developing dementia. BCAS in mice reduced cerebral blood flow by 52% (P<0.01) and thickened carotid artery walls, regardless of EE duration. Remarkably, the total and cortical infarcts declined by >50% in BCAS mice exposed to EE compared with BCAS-Std (P<0.01). Frontal lobe and cortical strokes were associated with worsening working memory tested in a radial maze paradigm. Proteomic analysis revealed EE, both BCAS-3hrs and BCAS-Full attenuated coagulation cascade factors including fibrinogen and von Willebrand factor, markers of blood-brain barrier damage.

Small cortical and subcortical infarcts were evident in both post-stroke survivors with CAD and BCAS mice. Experimental evidence suggested that moderate exposure to EE is sufficient to reduce subsequent stroke lesions.

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Depositing User: Abdelkader Ennaceur


Item ID: 10665
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ISSN: 1365-2990
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ORCID for Abdelkader Ennaceur: ORCID iD

Catalogue record

Date Deposited: 30 May 2019 10:28
Last Modified: 04 Feb 2021 19:27


Author: Abdelkader Ennaceur ORCID iD
Author: Yoshiki Hase
Author: Tuomo M. Polvikoski
Author: Masafumi Ihara
Author: Mai Hase
Author: Rayyan Zafar
Author: William Stevenson
Author: Louise M. Allan
Author: Karen Horsburgh
Author: Xavier Gallart‐Palau
Author: Kwan Sze Siu
Author: Raj N Kalaria
Author: Yoshiki Hase
["contributor_type_typename_" not defined]: Tuomo M. Polvikoski
["contributor_type_typename_" not defined]: Masafumi Ihara
["contributor_type_typename_" not defined]: Mai Hase
["contributor_type_typename_" not defined]: Rayyan Zafar
["contributor_type_typename_" not defined]: William Stevenson
["contributor_type_typename_" not defined]: Louise M Allan
["contributor_type_typename_" not defined]: Abdelkader Ennaceur
["contributor_type_typename_" not defined]: Karen Horsburgh
["contributor_type_typename_" not defined]: Xavier Gallart-Palau
["contributor_type_typename_" not defined]: Kwan Sze Siu
["contributor_type_typename_" not defined]: Raj N Kalaria

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Biomedical Sciences
Sciences > Health Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology

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