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Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid

Rashid, Fatimah, Albayati, Mustafa and Dodou, Kalliopi (2019) Studies on Novel Methods for Formulating Novel Cross-Linked Hydrogel Films of Hyaluronic Acid. Cosmetics, 6 (4). pp. 59-78. ISSN 2079-9284

Item Type: Article


Hyaluronic acid (HA) is a natural polysaccharide with promising applications in modern cosmetic and nutricosmetic products due to its high-water affinity, which is essential for skin hydration, as well as its biocompatibility, biodegradability, non-toxicity, and non-immunogenic nature. In this study, we investigated and optimized the method of crosslinking for formulating novel HA hydrogel films. We used Pentaerythritol Tetra-acrylate (PT) as the cross-linking agent over a range of pH values and used different cross-linking methods (Ultraviolet (UV) radiation, microwaving, and oven heating). The efficacy of the cross-linking reaction was evaluated using swelling studies and Fourier transform infrared (FTIR) spectroscopy for the characterization of the xerogel HA-PT film formulations. We found that HA-PT cross-linked hydrogels are produced under alkaline conditions (pH 11) but not under neutral or acidic conditions. Cross-linked HA-PT xerogel films using UV-irradiation showed excessive swelling indicative of inadequate cross-linking. The oven and microwaving methods produced HA-PT films with high cross-linking density. FTIR data suggest formation of ester bond between the carbonyl of the HA and hydroxyl group of the PT acrylate group. Overall, the oven method was considered better and easier than UV-radiation/microwave methods because it is safer, user-friendly and eco-friendly, and can process larger batches.

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Depositing User: Kalli Dodou


Item ID: 11176
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ISSN: 2079-9284
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ORCID for Kalliopi Dodou: ORCID iD

Catalogue record

Date Deposited: 04 Oct 2019 12:57
Last Modified: 30 Sep 2020 11:17


Author: Kalliopi Dodou ORCID iD
Author: Fatimah Rashid
Author: Mustafa Albayati

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Chemistry
Sciences > Health Sciences
Sciences > Pharmacy and Pharmacology

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