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APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps

Rezasoltani, Sama, Hadizadeh, Mahrooyeh, Golmohammadi, Mina, Nazemalhossini-Mojarad, Ehsan, Salari, Sina, Rezvani, Hamid, Asadzadeh-Aghdaei, Hamid, Ladomery, Michael, Young, Chris, Anaraki, Fakhrosadat, Almond, Sarah and Ashrafian Bonab, Maziar (2020) APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps. Cancer Informatics, 19. pp. 1-8. ISSN 1176-9351

Item Type: Article


ABSTRACT: Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and hyperplastic (HP) polyps in an Iranian patient population. Thus, we highlight potential gene expression profiles as candidate novel biomarkers for the early detection of CRC. From a 12-month study (2016-2017), 44 biopsy samples were collected during colonoscopy from the patients with colorectal polyps and 10 healthy subjects for normalization. Clinical and demographic data were collected in all cases, and mRNA expression of APC, CTNNB1, CDH1, AXIN1, and AXIN2 genes was investigated using real-time polymerase chain reaction (PCR). CTNNB1 and CDH1 expression levels were unaltered in AP and HP subjects, whereas mRNA expression of APC was decreased in AP contrasted with HP subjects, with a significant
association between APC downregulation and polyp size. Although AXIN1 showed no changes between AP and HP groups, a significant association between AXIN1 and dysplasia grade was found. Also, significant upregulation of AXIN2 in both AP and HP subjects was detected.
In summary, we have shown increased expression of AXIN2 and decreased expression of APC correlating with grade of dysplasia and polyp size. Hence, AXIN2 and APC should be explored as biomarker candidates for early detection of AP and HP polyps in CRC.

Keywords : Colorectal polyps, gene expression, WNT/CTNNB1 signaling, colorectal cancer, biomarker

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Depositing User: Maziar Ashrafian Bonab


Item ID: 12803
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ISSN: 1176-9351
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ORCID for Maziar Ashrafian Bonab: ORCID iD

Catalogue record

Date Deposited: 20 Nov 2020 14:28
Last Modified: 20 Nov 2020 14:30


Author: Maziar Ashrafian Bonab ORCID iD
Author: Sama Rezasoltani
Author: Mahrooyeh Hadizadeh
Author: Mina Golmohammadi
Author: Ehsan Nazemalhossini-Mojarad
Author: Sina Salari
Author: Hamid Rezvani
Author: Hamid Asadzadeh-Aghdaei
Author: Michael Ladomery
Author: Chris Young
Author: Fakhrosadat Anaraki
Author: Sarah Almond

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences
Sciences > Chemistry
Sciences > Health Sciences

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