The effective function of circular RNA in colorectal cancer

Ameli-Mojarad, Mandana, Ameli‑Mojarad, Melika, Hadizadeh, Mahrooyeh, Young, Chris, Babini, Hosna, Nazemalhosseini‑Mojarad, Ehsan and Ashrafian Bonab, Maziar (2021) The effective function of circular RNA in colorectal cancer. Cancer Cell International, 21 (496). ISSN 1475-2867

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Abstract

Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Sciences > Chemistry
Sciences > Health Sciences
Divisions: Faculty of Health Sciences and Wellbeing > School of Medicine
Related URLs:
Depositing User: Maziar Ashrafian Bonab
Date Deposited: 23 Sep 2021 10:48
Last Modified: 28 Sep 2021 14:20
URI: http://sure.sunderland.ac.uk/id/eprint/14054

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