Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

The Role of Dopamine D3 Receptors in Tobacco Use Disorder: A Synthesis of the Preclinical and Clinical Literature.

Butler, Kevin, Le Foll, Bernard and Di Ciano, Patricia (2022) The Role of Dopamine D3 Receptors in Tobacco Use Disorder: A Synthesis of the Preclinical and Clinical Literature. In: Therapeutic Applications of Dopamine D3 Receptor Action. Current Topics in Behavioral Neurosciences . Springer, Berlin, Heidelberg.

Item Type: Book Section


Tobacco smoking is a significant cause of preventable morbidity and mortality globally. Current pharmacological approaches to treat tobacco use disorder (TUD) are only partly effective and novel approaches are needed. Dopamine has a well-established role in substance use disorders, including TUD, and there has been a long-standing interest in developing agents that target the dopaminergic system to treat substance use disorders. Dopamine has 5 receptor subtypes (DRD1 to DRD5). Given the localization and safety profile of the dopamine receptor D3 (DRD3), it is of therapeutic potential for TUD. In this chapter, the preclinical and clinical literature investigating the role of DRD3 in processes relevant to TUD will be reviewed, including in nicotine reinforcement, drug reinstatement, conditioned stimuli and cue-reactivity, executive function, and withdrawal. Similarities and differences in findings from the animal and human work will be synthesized and findings will be discussed in relation to the therapeutic potential of targeting DRD3 in TUD.

[img] PDF
D3 TUD Chapter Authors Accepted Version.pdf - Accepted Version
Restricted to Repository staff only

Download (943kB) | Request a copy

More Information

Uncontrolled Keywords: Dopamine; Dopamine receptor D3; Nicotine dependence; Smoking cessation; Tobacco use disorder
Depositing User: Kevin Butler


Item ID: 15410
ISSN: 1866-3370
Official URL:

Users with ORCIDS

ORCID for Kevin Butler: ORCID iD

Catalogue record

Date Deposited: 11 Nov 2022 15:03
Last Modified: 24 Jan 2023 10:01


Author: Kevin Butler ORCID iD
Author: Bernard Le Foll
Author: Patricia Di Ciano

University Divisions

Faculty of Health Sciences and Wellbeing > School of Psychology


Sciences > Pharmacy and Pharmacology

Actions (login required)

View Item View Item