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Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance

Myssina, Svetlana, Clark-Corrigall, John, Michaelis, Martin, Cinatl, Jindrich, Ahmed, Shafiq and Carr-Wilkinson, Jane (2022) Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance. Cancer Investigation, 41 (2). pp. 173-182. ISSN 0735-7907

Item Type: Article


Neuroblastoma (NB) is a paediatric solid cancer with high fatality, relapses and acquired resistance to chemotherapy that requires new therapeutic approaches to improve survival.
LGR5 is a receptor that potentiates WNT/ signalling pathway and has been reported to promote development and survival in several adult cancers.
In this study we investigated LGR5 expression in a panel of NB cell lines with acquired resistance to vincristine or doxorubicin.
We show LGR5-LRP6 cooperation with enhanced expression in drug resistant NB cell lines compared to parental cells, suggesting a role for LGR5 in the emergence of drug resistance, warranting further investigation

Key words: LGR5, LRP6, WNT pathway, neuroblastoma, acquired drug resistance.

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449785v2.full JCW 171022.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

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Depositing User: Jane Carr-Wilkinson


Item ID: 16189
Identification Number:
ISSN: 0735-7907
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Catalogue record

Date Deposited: 01 Jun 2023 16:20
Last Modified: 06 Nov 2023 03:38


Author: Svetlana Myssina
Author: John Clark-Corrigall
Author: Martin Michaelis
Author: Jindrich Cinatl
Author: Shafiq Ahmed
Author: Jane Carr-Wilkinson

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences

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