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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

An investigation of Digoxin by Cyclic Voltammetry using Gold and Silver Solid Electrodes and Chemometric Analysis

Bellia, G.F., Corrall, H., Baron, M.G., Croxton, Ruth and Gonzalez-Rodriguez, J. (2023) An investigation of Digoxin by Cyclic Voltammetry using Gold and Silver Solid Electrodes and Chemometric Analysis. International Journal of Electrochemical Science, 12 (4). pp. 3050-3062. ISSN 1452-3981

Item Type: Article


Digoxin, one of the main cardiac glycosides medication, has shown to have a strong analytical response under investigation by voltammetric analysis using mercury electrodes, achieving nanomole sensitivity. In this study we investigated the suitability of solid electrodes as gold and silver electrodes in voltammetric analysis of this active pharmaceutical ingredient. The scope of the investigation was to evaluate if the use of these solid electrodes, more practical and especially less dangerous, under an operative and environmental aspects could represent a valid further possibility to add to the use of the mercury ones. Both of the solid electrodes have been tested at different pH of 5, 7.4, 10, and 11. PCA analysis has been performed and specific responses achieved. Micromole sensitivity has been achieved for both of the electrodes, showing that the use of these sensors could represent a preliminary analytical approach when the more accurate alternative choice is not necessary, being more practical and less environmental impacting than using mercury.

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Depositing User: Ruth Croxton


Item ID: 16568
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ISSN: 1452-3981
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Users with ORCIDS

ORCID for Ruth Croxton: ORCID iD

Catalogue record

Date Deposited: 26 Feb 2024 10:35
Last Modified: 26 Feb 2024 10:45


Author: Ruth Croxton ORCID iD
Author: G.F. Bellia
Author: H. Corrall
Author: M.G. Baron
Author: J. Gonzalez-Rodriguez

University Divisions

Faculty of Health Sciences and Wellbeing > School of Psychology


Sciences > Chemistry

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