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The development and validation of a digital biomarker for remote assessment of Alzheimer's Diseases Risk.

Butler, Joe, Watermeyer, Tamlyn, Matterson, Ellie, Harper, Ellie and Parra-Rodriguez, Mario (2024) The development and validation of a digital biomarker for remote assessment of Alzheimer's Diseases Risk. Digital Health, 10. ISSN 2055-2076

Item Type: Article


Digital cognitive assessment is becoming increasingly widespread in ageing research and care, especially since the COVID19 pandemic. Remote online collection provides opportunities for ageing and dementia professionals to collect larger datasets, increase the diversity of research participants and patients and offer cost-effective screening and monitoring methods for clinical practice and trials. However, the reliability of self-administered at-home tests compared to their lab-based counterparts often goes unexamined, compromising the validity of adopting such measures.

Our aim is to validate a self-administered web-based version of the visual short-term memory binding task (VSTMBT), a potential digital biomarker sensitive to Alzheimer’s Disease processes, suitable for use on personal devices.

A final cross-sectional sample of 37 older-adult (51 – 77 years) participants without dementia completed our novel self-administered version of the VSTMBT, both at home on a personal device and in the lab, under researcher-controlled conditions.

ANOVA and Bayesian T-test found no significant differences between the task when it was remotely self-administered by participants at home compared to when it was taken under controlled lab conditions.

These results indicate the VSTMBT can provide reliable data when self-administered at-home using an online version of the task and on a personal device. This finding has important implications for remote screening and monitoring practices of older adults, as well as supporting clinical practices serving diverse patient communities. Future work will assess remote administration in older adults with cognitive impairment and diverse socio-economic and ethno-cultural backgrounds as well as a bench-to-bedside application.

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More Information

Depositing User: Joe Butler


Item ID: 17215
Identification Number:
ISSN: 2055-2076
Official URL:

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Catalogue record

Date Deposited: 16 Jan 2024 09:38
Last Modified: 29 Apr 2024 10:15


Author: Joe Butler
Author: Tamlyn Watermeyer
Author: Ellie Matterson
Author: Ellie Harper
Author: Mario Parra-Rodriguez

University Divisions

Faculty of Health Sciences and Wellbeing > School of Psychology


Sciences > Health Sciences
Psychology > Neuropsychology

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