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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Hit validation of ERK5 inhibitors: Expectations and challenges

Myers, SM (2012) Hit validation of ERK5 inhibitors: Expectations and challenges. In: ACS 243rd National Meeting and Exposition, 25-29 Mar 2012, San Diego, USA.

Item Type: Conference or Workshop Item (Poster)


Extracellular signal-regulated kinase 5 (ERK5) plays a key role in the transduction of extracellular signals to intracellular effectors. Activation of the ERK5 signalling pathway is associated with cell survival and proliferation, and thus ERK5 over-expression has implications in carcinogenesis. Inhibiting ERK5 is therefore an effective approach for anti-cancer therapy. Following a high throughput screening campaign, three chemical series (1 -3) were selected for validation. The syntheses and biological evaluation of novel benzo[d]thiazoles (1), 4-aminopyrimidine-5-carbonitriles (2) and 3 cyanopyridines (3) will be discussed.


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Depositing User: Stephanie Myers


Item ID: 17743
Official URL:

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Date Deposited: 26 Jun 2024 10:50
Last Modified: 26 Jun 2024 11:00


Author: SM Myers
Author: Stephanie Myers

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Chemistry
Sciences > Pharmacy and Pharmacology

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