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Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Mahita, Mwajuma, Abuhamdah, Rushdie, Howes, Melanie-Jayne, Ennaceur, Abdelkader, Abuhamdah, S and Chazot, Paul (2014) Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils. European Journal of Medicinal Plants, 4 (7). pp. 810-818. ISSN 2231-0894

Item Type: Article


Aims: Melissa officinalis (Mo) and Lavandula angustifolia (La) essential oils and their major constituents ((E) - caryophyllene, caryophyllene oxide, geranyl acetate, linalool, nerol, Oct-1-en-3-ol, 3-Octanone, myrcene, allo-ocimene, p-cymene and α- terpineol) assessed by GC-MS) which are shared by these two essential oils were probed in an attempt to identify the GABAAR ligand(s).
Study Design: [35S] t-butylbicyclophosphorothionate (TBPS) radioligand binding assay to GABAA receptors. In vitro neuronal viability assay.
Place and Duration of Study: School of Biological and Biomedical Sciences, Durham University, United Kingdom (December 2012 and January 2013).
Results: One of the major component (s) of (Mo), trans-ocimene, inhibited [35S] (TBPS) binding to native GABAA receptors in a concentration-dependent manner with an apparent IC50 of 40μM.
Concentrations (0.001 mg/ml) of whole (Mo) were shown to display modest beneficial effects upon neuronal viability while at a higher concentration (0.1 mg/ml) of (Mo) and (La) oils induced a neurotoxicity effect.
Conclusion: These data provide the first evidence that allo-ocimene is an neuroactive GABAA R inhibitory component found in both (Mo) and (La), and represents a novel GABAA receptor channel chemotype derived from a natural product. - See more at:

Identification_of_a_Novel_GABAA_Receptor_Channel_Ligand_Derived_from_Melissa_officinalis_and_Lavandula_angustifolia_Essential_Oils..pdf - Published Version

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Depositing User: Abdelkader Ennaceur


Item ID: 5099
Identification Number:
ISSN: 2231-0894
Official URL:

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ORCID for Abdelkader Ennaceur: ORCID iD

Catalogue record

Date Deposited: 24 Sep 2014 12:14
Last Modified: 18 Dec 2019 15:37


Author: Abdelkader Ennaceur ORCID iD
Author: Mwajuma Mahita
Author: Rushdie Abuhamdah
Author: Melanie-Jayne Howes
Author: S Abuhamdah
Author: Paul Chazot

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Biomedical Sciences
Sciences > Chemistry
Sciences > Pharmacy and Pharmacology

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