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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Effect of piracetam on learned helplessness

Cavoy, Albert, Ennaceur, Abdelkader and Delacour, J (1988) Effect of piracetam on learned helplessness. Physiology & Behavior, 42 (6). pp. 545-549. ISSN 0031-9384

Item Type: Article


In rats, the effects of Piracetam (P), the prototype of nootropic drugs, were studied on a very widely used model of behavioral disturbance: the learned helplessness (LH) phenomenon. In this model, exposure to uncontrollable and unsignalled shocks impairs subsequent escape-avoidance learning. In a first experiment, this deficit was abolished by 200 mg/kg of P, and to a lesser extent, by a 100 mg/kg dose, administered before the training session. In non-stressed animals, no dose of P was able to have a facilitatory effect on escape-avoidance. In a second experiment, the administration of P, not before the training session as in Experiment I, but before the stress, had no effect on the LH phenomenon regardless of the dose.

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Depositing User: Abdelkader Ennaceur


Item ID: 8100
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ISSN: 0031-9384
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ORCID for Abdelkader Ennaceur: ORCID iD

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Date Deposited: 16 Oct 2017 10:50
Last Modified: 18 Dec 2019 15:41