SURE

Article

Moosa, Najla Yussuf, Ahmed, Shafiq, Azeem, Sara Abdullah and Cheung, William (2024) Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. International Journal of Molecular Sciences, 25 (19). p. 10428. ISSN 1661-6596

Moosa, Najla Yussuf, Azeem, Sara Abdullah, Lodge, John K, Cheung, William and Ahmed, Shafiq (2024) Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. International journal of molecular sciences, 25 (10428). p. 10428. ISSN 1422-0067

Carruthers, Ross D., Ahmed, Shafiq, Ramachandran, Shaliny, Strathdee, Karen, Kurian, Kathreena M., Hedley, Ann, Gomez-Roman, Natividad, Kalna, Gabriela, Neilson, Mathew, Gilmour, Lesley, Stevenson, Katrina H., Hammond, Ester M. and Chalmers, Anthony J. (2018) Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells. Cancer Research, 78 (17). pp. 5060-5071. ISSN 0008-5472

Ahmed, Shafiq, Carruthers, R., Biasoli, D., Gomez-Roman, N., Gilmour, L., Strathdee, K., Hedley, A., Kalna, G., Hammond, E. and Chalmers, A. J. (2016) P08.36 Radioresistance of glioblastoma stem-like cells is associated with DNA replication stress, which is a promising therapeutic target. Neuro-Oncology, 18 (s4). iv49. ISSN 1522-8517

Kaur, A., Denisova, O., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, Shafiq, Raheem, O., Haapasalo, H. K., Eriksson, J., Chalmers, A. J., Laakkonen, P. M. and Westermarck, J. (2016) PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Research, 76 (23). pp. 7001-7011. ISSN 0008-5472

Tardito, S, Oudin, A, Ahmed, Shafiq, Fack, F, Keunen, O, Zheng, L, Miletic, H, Sakariassen, P, Weinstock, A, Wagner, A, Lindsay, S, Hock, A, Barnett, S, Ruppin, E, Morkve, S, Lund-Johansen, M, Chalmers, A, Bjerkvig, R, Niclou, S and Gottlieb, E (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restriced glioblastoma. Nature Cell Biology, 17 (12). pp. 1556-1568. ISSN 1465-7392

Ahmed, Shafiq, Carruthers, R, Gilmour, L, Yildirim, S, Watts, C and Chalmers, A (2015) Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells. Cancer Research, 75 (20). pp. 4416-4428. ISSN 0008-5472

Ichim, G, Lopez, J, Ahmed, Shafiq, Muthalagu, N, Giampazolias, E, Delgado, E, Haller, Martina, Riley, Joel S, Mason, Susan, Athineos, Dimitris, Parsons, MJ, Kooij, BVD, Bouchier-Hayes, L, Chalmers, A, Rooswinkel, R, Oberst, A, Blyth, K, Rehm, M, Murphy, D and Tait, S (2015) Limited mitochondrial permeabilisation causes DNA-damage and genomic instability in the absence of cell death. Molecular Cell, 57 (5). pp. 860-872. ISSN 1097-2765

Carruthers, R, Ahmed, Shafiq, Strathdee, Karen, Gomez-Roman, N, Amoah-Buahin, E, Watts, C and Chalmers, A (2014) Abrogation of radioresistance in in glioblastoma stem-like cells by inhibition of ATM kinase. Molecular Oncology, 9 (1). pp. 192-203. ISSN 1878-0261

Blackburn, TJ, Ahmed, Shafiq, Coxon, CR, Liu, J, Lu, X, Golding, BT, Griffin, RJ, Hutton, C, Newell, DR, Ojo, S, Watson, AF, Zaytzev, A, Zhao, Y, Lunec, J and Hardcastle, IR (2013) Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions. Med. Chem. Commun., 4 (9). pp. 1297-1304.

Shah, Z, Ahmed, Shafiq, Ford, J, Allison, S, Knight, J and Milner, J (2012) A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes. Mol Cell Biol., 32 (3). pp. 704-716.

Hardcastle, IR, Liu, J, Valeur, E, Watson, A, Ahmed, Shafiq, Blackburn, TJ, Bennaceur, K, Clegg, W, Drummond, C, Endicott, JA, Golding, BT, Griffin, RJ, Gruber, J, Haggerty, K, Harrington, RW, Hutton, C, Kemp, S, Lu, X, McDonnell, JM, Newell, DR, Noble, ME, Payne, SL, Revill, CH, Riedinger, C, Xu, Q and Lunec, J (2011) Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency. J Med Chem, 54 (5). pp. 1233-43.

Lynch, CJ, Shah, ZH, Allison, SJ, Ahmed, Shafiq, Ford, J, Warnock, LJ, Li, H, Serrano, M and Milner, J (2010) SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS ONE, 4 (10).

Ahmed, Shafiq and Milner, J (2009) Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network. PLoS ONE, 4 (10).

Ford, J, Ahmed, Shafiq, Allison, S, Jiang, M and Milner, J (2008) JNK2 dependent regulation of SIRT1 protein stability. Cell Cycle, 7 (19). pp. 3091-3097.

Hardcastle, IR, Ahmed, Shafiq, Atkins, H, Farnie, G, Golding, BT, Griffin, RJ, Guyenne, S, Hutton, C, Kallblad, P, Kemp, SJ, Kitching, MS, Newell, DR, Norbedo, S, Northen, JS, Reid, RJ, Saravanan, K, Willems, HM and Lunec, J (2006) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem, 49 (21). pp. 6209-6221.

Hardcastle, IR, Ahmed, Shafiq, Atkins, H, Calvert, AH, Curtin, NJ, Farnie, G, Golding, BT, Griffin, RJ, Guyenne, S, Hutton, C, Kallblad, P, Kemp, SJ, Kitching, MS, Newell, DR, Norbedo, S, Northen, JS, Reid, RJ, Saravanan, K, Willems, H and Lunec, J (2005) Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters, 15 (5). pp. 1515-1520.

Conference or Workshop Item

Mysina, Svetlana, Ahmed, Shafiq, Michaelis, Martin, Cinatl Jr, Jindrich, Adejuwon, Damilola, Zaka, Masood and Carr-Wilkinson, Jane (2018) Investigating the role of cancer stem cell related genes in acquired drug resistance in neuroblastoma. In: Advances in Neuroblastoma Research 2018, May 9th -12th 2018, San Francisco.

Ahmed, Shafiq (2016) High throughput screening campaigns for the development of novel therapeutics in Glioblastomas. In: Academic Screening Group Meeting, 6 May 2016, CRUK Manchester. (Unpublished)