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Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze

Ennaceur, Abdelkader and Hussain, Muhammed Dilwar (2015) Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze. Stress. pp. 1-9. ISSN 1025-3890

Item Type: Article

Abstract

Here we used a 3-dimensional (3D) maze, a modification of the radial maze, to assess the effects of treatment for two weeks with a single daily dose of fluoxetine (20 mg/kg, i.p.) on anxiety in male BALB/c mice. We examined whether anxiolytic effects of fluoxetine can be detected over three daily test sessions. We examined also whether repeated handling associated with chronic treatment interferes with effects of fluoxetine on anxiety responses. The 3D maze comprises 9 arms, each connected to an upward inclined bridge radiating from a central platform. In this maze, BALB/c mice cross frequently into the bridges but avoid the arms. This avoidance is used as an index of anxiety. Two separate groups received once a day either saline (SALCH, n=8) or fluoxetine (FLUCH, n=8) for 14 days, and up to 30 min before the test during the subsequent 3 days. A third group received saline (SALAC, n=8) 30 min before the test, once a day for 3 days. SALAC mice did not cross into the arms, and continued this avoidance over 3 sessions. SALCH mice avoided the arms in session 1 whereas FLUCH mice did cross into the arms, and like SALCH mice, increased number of crossings into and time on the arms in subsequent sessions. Fluoxetine evidently had an anxiolytic effect but only in the first session. These results indicate that handling experience decreased fear and anxiety in the mice, which may have masked the anxiolytic effect of fluoxetine in the second and third test sessions.

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Depositing User: Abdelkader Ennaceur

Identifiers

Item ID: 5757
Identification Number: https://doi.org/10.3109/10253890.2015.1083550
ISSN: 1025-3890
URI: http://sure.sunderland.ac.uk/id/eprint/5757
Official URL: http://www.tandfonline.com/loi/ists20

Users with ORCIDS

ORCID for Abdelkader Ennaceur: ORCID iD orcid.org/0000-0001-6398-4383

Catalogue record

Date Deposited: 02 Oct 2015 09:24
Last Modified: 18 Dec 2019 15:38

Contributors

Author: Abdelkader Ennaceur ORCID iD
Author: Muhammed Dilwar Hussain
Author: Abdelkader Ennaceur
Author: Muhammed Hussain

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences > Biomedical Sciences
Sciences > Pharmacy and Pharmacology
Psychology > Psychology

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