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Chronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37

Borrello, Maria Teresa and Mann, Derek (2022) Chronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37. British Journal of Pharmacology. ISSN 1476-5381

Item Type: Article


Chronic liver diseases comprise a broad spectrum of burdensome diseases that still lack effective pharmacological therapies. Our research group focuses on fibrosis, which is a major precursor of liver cirrhosis. Fibrosis consists in a progressive disturbance of liver sinusoidal architecture characterised by connective tissue deposition as a reparative response to tissue injury. Multifactorial events and several types of cells participate in fibrosis initiation and progression, and the process still needs to be completely understood. The development of experimental models of liver fibrosis alongside the identification of critical factors progressing fibrosis to cirrhosis will facilitate the development of more effective therapeutic approaches for such condition. This review provides an overlook of the main process leading to hepatic fibrosis and therapeutic approaches that have emerged from a deep knowledge of the molecular regulation of fibrogenesis in the liver.

British J Pharmacology - 2022 - Borrello - Chronic liver diseases From development to novel pharmacological therapies .pdf - Published Version
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Uncontrolled Keywords: chronic liver diseases; fibrosis; fibrosis therapy; macrophages; pharmacology of chronic liver diseases
Depositing User: Teresa Borrello


Item ID: 15988
Identification Number:
ISSN: 1476-5381
Official URL:

Users with ORCIDS

ORCID for Maria Teresa Borrello: ORCID iD

Catalogue record

Date Deposited: 05 May 2023 14:18
Last Modified: 11 Jul 2023 08:02


Author: Maria Teresa Borrello ORCID iD
Author: Derek Mann

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Chemistry
Sciences > Health Sciences
Sciences > Pharmacy and Pharmacology

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